How to Treat Cluster Headaches with Psychedelics

Cluster headaches are one of the most intensely painful experiences and can be debilitating to sufferers, often leading to suicide. Many people believe they are the single most painful human experience. From Newsweek:

"I would rather give birth without a painkiller than get 'hit,' " says Becky Ulissi, referring to a cluster headache attack, of which she has up to eight each day.

LSD and psilocybin mushrooms have shown remarkable results in reducing or eliminating cluster headaches for weeks or months following a single treatment. The impact is life changing for sufferers. Among all the powerful and important uses of psychedelics, the incredible and immediate positive effect for cluster headache sufferers is potentially the most clear cut and urgent.

If you know anyone who suffers from this condition and has not tried these approaches, we urge you to send them information about patient experiences (see below).

If you are interested in learning how to use psychedelics to treat cluster headaches, please take a look at the Clusterbusters discussion group, search the group for 'LSD' and 'mushrooms' to read about patient experiences and recommendations. Also, take a look at our step by step LSD Guide and our Mushrooms Guide.

Have you used psychedelics to treat cluster headaches? We’d love to hear your story. Please write to us at

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